Cellular Mechanisms Contributing to Endothelial Dysfunction in NAA

Abstract

Nonspecific aortoarteritis (NАA) is known to be a common systemic vasculitis affecting the aorta and large major vessels. NАA more often affects middle-aged people from 30 to 40 years old, and in these patients, NАA acts as a risk factor for the development (RDF) of atherosclerosis, coronary heart disease, heart failure in 74% of patients with NAA, arterial hypertension (AH), the leading clinical syndrome. The etiology of AH can be hemodynamic disturbances, cerebral ischemia, as well as other nosologies. AH in patients is a powerful RDF of formation and pathology from both the heart and blood vessels [1, 3, 5].

An important role in the dynamics in the status of the vascular wall (VW) is assigned to the inner layer of blood vessels - it is anatomically called endothelium and it is important to emphasize: it is the main "target organ" in NАA. When exposed to destructive agents, the compeNAAtory function of the vascular endothelium is disturbed, which contributes to the destruction of physiological, biochemical and immunological mechanisms in VW [1, 2, 4, 6].